مقالاتی در ارتباط با پدیکولوزیس(شپش سر)

Effectiveness of isopropyl myristate/cyclomethicone D5 solution of removing cuticular hydrocarbons from human head lice

Eric Barnett1*, Kathleen G Palma1, Bert Clayton1 and Timothy Ballard2

Barnett et al. BMC Dermatology 2012, 12:15

Abstract
Background: In the treatment of human head lice infestation, healthcare providers are increasingly concerned
about lice becoming resistant to existing pesticide treatments. Traditional pesticides, used to control these pests,
have a neurological mechanism of action. This publication describes a topical solution with a non-traditional
mechanism of action, based on physical disruption of the wax layer that covers the cuticle of the louse exoskeleton.
This topical solution has been shown clinically to cure 82% of patients with only a 10-minute treatment time,
repeated once after 7 days. All insects, including human head lice, have a wax-covered exoskeleton. This wax,
composed of hydrocarbons, provides the insect with protection against water loss and is therefore critical to its
survival. When the protective wax is disrupted, water loss becomes uncontrollable and irreversible, leading to
dehydration and death. A specific pattern of hydrocarbons has been found in all of the head louse cuticular wax
studied. Iso-octane effectively removes these hydrocarbons from human head lice’s cuticular wax

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